Antioxidation, Thrombolysis, Cytotoxicity and Antibacterial Activity of Leaves Vitex

Abstract

Vitex peduncularis (Verbenaceae), a perennial tree, is used locally because of its versatility. Pharmacological properties include analgesic, antimalarial, antianginal, antidiabetic, antioxidant, Anti-inflammatory and hepatoprotective. Therefore, in this study, the antioxidant, thrombolytic, cytotoxic and antibacterial activities of crude methanol extract and various substances thereof were evaluated. solvent fraction. Data from antioxidant and thrombolysis tests were provided by the Kupchan Division. The chloroform-soluble fraction showed the largest phenol content (73.39 mg GAE/g extract), DPPH radical scavenging activity (26.69 μg/ml) and thrombolytic activity (37.35%). In brine shrimp lethality assessments, the LC50 values ​​were the most cytotoxic compounds. Found in the ethyl acetate soluble fraction (LC50 6.73 µg/ml). Finally, antibacterial activity Other fractions show mild activity of both chloroform and methanol fractions. against the bacteria tested. Potential biological effects of crude oil fractions have been demonstrated and future studies on isolated compounds are needed to evaluate these activities.